| The characters and the actors who played them are only named in the sections of the play in which they first appear. |
| The Nickleby Family |
| Nicholas Nickleby | Michael Siberry |
| Kate Nickleby | Denica Fairman |
| Ralph Nickleby | John Carlisle |
| Mrs Nickleby | Frances Cuka |
| London |
| Newman Noggs | David Collings |
| Hannah | Jane Whittenshaw |
| Miss La Creevy | Eve Pearce |
| Sir Matthew Pupker | Hubert Rees |
| Mr Bonney | Alan Gill |
| Irate Gentleman | George Raistrick |
| Flunkey | Timothy Kightley |
| Muffin Boys | Ian East/Alan Hendrick |
| Mr Snawley | Richard Simpson |
| Snawley Major | Jane Whittenshaw |
| Snawley Minor | Raymond Platt |
| Belling | Alan Hendrick |
| William | Jimmy Yuill |
| Waitresses | Karen Lancaster/Rebecca Saire |
| Coachman | George Raistrick |
| Mr Mantalini | Alan David |
| Madame Mantalini | Karen Archer |
| Flunkey | Jimmy Gardner |
| Miss Knag | Frances Cuka |
| Rich Ladies | Sharon Bower/Rebecca Saire |
| Milliners | Jane Carr/Ian East/Alan Hendrick/Karen Lancaster/Eve Pearce/Raymond Platt/Alison Rose/Richard Simpson/Jane Whittenshaw |
| Yorkshire |
| Mr Squeers | David Delve |
| Mrs Squeers | Pat Keen |
| Smike | John Lynch |
| Phib | Rebecca Saire |
| Fanny Squeers | Jane Carr |
| Young Wackford Squeers | Jimmy Yuill |
| John Browdie | Clive Wood |
| Tilda Price | Alison Rose |
| Boys |
| Tomkins | Tim Kightley |
| Coates | Jimmy Gardner |
| Graymarsh | Alan Gill |
| Jennings | George Raistrick |
| Mobbs | Alan David |
| Bolder | Brian Torfeh |
| Pitcher | Karen Lancaster |
| Jackson | Simon Templeman |
| Cobbey | Denica Fairman |
| Peters | Frances Cuka |
| Sprouter | Karen Archer |
| Roberts | Ian East |
| London Again |
| Mr Kenwigs | Patrick Godfrey |
| Mrs Kenwigs | Shirley King |
| Morleena Kenwigs | Jane Whittenshaw |
| Baby Kenwigs | Jane Carr |
| Mr Lilyvick | Timothy Kightley |
| Henrietta Petowker | Karen Lancaster |
| Mr Crowl | Ian East |
| George | Alan Gill |
| Mr Cutler | Richard Simpson |
| Mrs Cutler | Karen Archer |
| Mrs Kenwigs’ Sister | Rebecca Saire |
| Stout Lady | Eve Pearce |
| Miss Green | Frances Cuka |
| Babysitter | Alan Hendrick |
| Benjamin | Raymond Platt |
| Pugstyles | Roderick Horn |
| Old Lord | Jimmy Gardner |
| Young Fiancée | Alison Rose |
| Landlord | Tony Jay |
| Portsmouth |
| Mr Vincent Crummles | Tony Jay |
| Mrs Crummles | Pat Keen |
| The Infant Phenomenon | Alison Rose |
| Master Percy Crummles | Raymond Platt |
| Master Crummles | Brian Torfeh |
| Mrs Grudden | Eve Pearce |
| Miss Snevellicci | Jane Carr |
| Mr Folair | Alan David |
| Mr Lenville | Roderick Horn |
| Miss Ledrock | Rebecca Saire |
| Miss Bravassa | Karen Archer |
| Mr Wagstaff | David Delve |
| Mr Blightey | Richard Simpson |
| Miss Belvawney | Jane Whittenshaw |
| Mr Pailey | Jimmy Yuill |
| Mr Hetherington | Simon Templeman |
| Mr Bane | Alan Hendrick |
| Mr Fluggers | Jimmy Gardner |
| Mrs Lenville | Shirley King |
| Mr Curdle | Hubert Rees |
| Mrs Curdle | Denica Fairman |
| London Again |
| Scaley | Jimmy Yuill |
| Tix | Raymond Platt |
| Sir Mulberry Hawk | Clive Wood |
| Lord Frederick Verisopht | Simon Templeman |
| Mr Pluck | Raymond Platt |
| Mr Pyke | Brian Torfeh |
| Mr Snobb | Alan Hendrick |
| Colonel Chowser | Timothy Kightley |
| Brooker | George Raistrick |
| Mr Wititterley | Hubert Rees |
| Mrs Wititterley | Karen Aercher |
| Alphonse | Alan Hendrick |
| Opera Singers | Karen Lancaster/Brian Torfeh/Roderick Horn |
| Charles Cheeryble | Tim Kightley |
| Ned Cheeryble | Hubert Rees |
| Tim Linkinwater | Jimmy Gardner |
| The Gentleman in Small Clothes | Raymond Platt |
| Keeper | Alan Gill |
| Frank Cheeryble | Alan Hendrick |
| Nurse | Karen Archer |
| Madeline Bray | Rebecca Saire |
| Arthur Gride | Alan David |
| Walter Bray | Tony Jay |
| Peg Sliderskew | Jane Carr |
| Hawks’ Rival | David Collings |
| Captain Adams | Jimmy Yuill |
| Westwood | Alan Gill |
| Croupier | Tim Kightley |
| Surgeon | Richard Simpson |
| Umpire | Roderick Horn |
| Policemen | Simon Templeman/Brian Torfeh |
| Mrs Snawley | Karen Archer |
| Young Woman | Jane Whittenshaw |
| All other parts played by members of the company. |
